Preparation, expansion, and uses of adult pluripotent stem cells
US12203096B2 · kind B2 · utility
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Key dates
| Filing date | Sep 26, 2022 |
| Grant date | Jan 21, 2025 |
| Priority date | — |
| Expiry date | Sep 26, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Certain relatively small cells present in the periphery blood of mammals can be activated to form pluripotent stem cell populations. These small cells are generally less than five micrometers in diameter and are CD45-positive, and are referred to herein as CD45+ cells or dormant tiny cells. Accordingly, provided are cell populations and compositions with enriched dormant tiny cells from blood samples and methods and compositions for activating these dormant tiny cells. Upon differentiation, the activated stem cells can be used for various therapeutic purposes.
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