Methods of expanding cholangiocytes
US12203099B2 · kind B2 · utility
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Key dates
| Filing date | Jun 19, 2018 |
| Grant date | Jan 21, 2025 |
| Priority date | — |
| Expiry date | Aug 22, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to the expansion of primary cholangiocytes in the form of cholangiocyte organoids (COs) using culture conditions in which canonical Wnt signalling is inhibited and non-canonical Wnt/PCP signalling is potentiated. Methods of expanding primary cholangiocytes, expanded populations of cholangiocytes and medical applications of expanded cholangiocytes are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.