3-hydroxybutyryl-CoA dehydrogenase variants and methods of use
US12203102B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Jul 14, 2022 |
| Grant date | Jan 21, 2025 |
| Priority date | — |
| Expiry date | Jul 14, 2042 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides thiolases and polypeptide variants of 3-hydroxybutyryl-CoA dehydrogenase, nucleic acids encoding the same, vectors comprising the nucleic acids, and cells comprising the polypeptide variants and/or thiolase, the nucleic acids, and/or the vectors. The present disclosure also provides methods of making and using the same, including methods for culturing cells, and for the production of various products, including 3-hydroxybutyryl-CoA (3-HB-CoA), 3-hydroxybutyraldehyde (3-HBal), 3-hydroxybutyrate (3-HB), 1,3-butanediol (1,3-BDO), and esters and amides thereof, and products made from any of these.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.