Device for determining antimicrobial susceptibility of a microorganism

US12203125B2 · kind B2 · utility

Assignee

• Q-LINEA AB · SE

Inventors

• Jonas Jarvius · Uppsala, SE
• Jan Grawe · Uppsala, SE
• Ylva Molin · Uppsala, SE
• Markus Klintstedt · Uppsala, SE
• Mats Gullberg · Uppsala, SE

Key dates

• Filing date: Oct 1, 2020
• Grant date: Jan 21, 2025
• Expiry date: Sep 12, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12M41/48
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides methods for determining the antimicrobial susceptibility of a microorganism in a clinical sample said method comprising removing a test aliquot from a clinical sample culture before the culture reaches 0.5 McFarland units, isolating the microbial cells and transferring the cells into a suitable culture medium for microbial growth, and performing an AST assay using the isolated microbes, wherein the concentration of microbial cells in the microbial cells used to set up the AST assay is measured before the degree of microbial growth in the different growth conditions of the AST assay is measured. Devices for determining the antimicrobial susceptibility of a microorganism in a clinical sample are also provided.