Apparatus and methods relating to freezing at least part of a biological sample
US12207650B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2018 |
| Grant date | Jan 28, 2025 |
| Priority date | — |
| Expiry date | Jan 16, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N1/162
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a device for use in freezing at least part of a biological sample in a receptacle, e.g. a vial or a cryopreservation bag, the device comprising: a base; and a receptacle holder comprising: a first part configured to, with the receptacle held by the receptacle holder during cooling of the base using a cooler device, withdraw heat energy from a first portion of the receptacle at a first heat withdrawal rate; and a second part configured such that, with the receptacle held by the receptacle holder during cooling of the base using the cooler device, a second heat withdrawal rate of heat energy withdrawal from a second portion of the receptacle via the second part is less than the first heat withdrawal rate. A temperature gradient may be established in the sample to enable progressive solidification to occur in the sample. A receptable for use in freezing a biological sample, and a freezing method are disclosed also.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.