Graphene quantum dots-gadolinium ion chelate as magnetic resonance imaging contrast agent and preparation method thereof
US12214057B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 5, 2019 |
| Grant date | Feb 4, 2025 |
| Priority date | — |
| Expiry date | Apr 12, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC01P2006/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A graphene quantum dots-gadolinium ion chelate (Gd@GQDs) nanomaterial with hydrophilic groups on the surface has a preparation method that includes: preparing graphene oxide by using a Hummers method; subsequently, subjecting the graphene oxide to heating, oxidation, and purification to obtain pure graphene quantum dots; and finally, chelating the graphene quantum dots with Gd3+ to form stable Gd@GQDs. The Gd@GQDs is easily dispersed in water, phosphate buffered solution (PBS), biological medium and other aqueous system, has good biocompatibility and low cytotoxicity, shows an excellent T1-weighted contrast performance in a 1.5-Tesla magnetic resonance testing system, and has a relaxation rate r1 as high as 72 mM−1s−1, the value of r1 being 20 times higher than that of the current commercial T1-weighted magnetic resonance imaging contrast agent Gd-DTPA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.