Compositions and methods for internalizing enzymes
US12215138B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Nov 17, 2021 |
| Grant date | Feb 4, 2025 |
| Priority date | — |
| Expiry date | Jan 3, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for treating enzyme-deficiency diseases are disclosed. Multidomain therapeutic proteins containing an internalization effector binding domain and a lysosomal replacement enzyme activity are disclosed. The multidomain therapeutic proteins are capable of entering cells, segregating to the lysosome, and delivering the replacement enzyme activity to the lysosome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.