Compositions and methods for targeting γδ T cells with chimeric antigen receptors
US12215154B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Jan 18, 2019 |
| Grant date | Feb 4, 2025 |
| Priority date | — |
| Expiry date | Jun 8, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention includes compositions comprising a chimeric antigen receptor (CAR) specific for an GD T Cell receptor (anti-GD TCR CAR), vectors comprising the same, compositions comprising anti-GD TCR CAR vectors packaged in viral particles, and recombinant T cells or other effector cells comprising the anti-GD TCR CAR of the invention. The invention also includes methods of making a genetically modified T cell expressing an anti-GD TCR CAR wherein the expressed CAR comprises an extracellular domain that binds to GD T cells or to cells expressing a GD TCR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.