Patent · US Active

HER-2 targeted bispecific compositions and methods for making and using the same

US12215156B2 · kind B2 · utility

0Cited by

61References

8Claims

0Family size

Assignee

Amunix Pharmaceuticals, Inc. · US

Inventors

Volker Schellenberger · Palo Alto, US
Eric Johansen · Newark, US
Angela HENKENSIEFKEN · San Jose, US
Darragh MacCann · Belfast, GB
James McClory · Raharney, IE
Philipp Kuhn · Oberblockland, DE
André Frenzel · Braunschweig, DE
Bryan Irving · Woodside, US
Mika K. Derynck · South San Francisco, US

Key dates

Filing date	Oct 25, 2023
Grant date	Feb 4, 2025
Priority date	—
Expiry date	Oct 25, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2800/101
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.