CD25 antibodies

US12215163B2 · kind B2 · utility

Assignee

• iBio, Inc. · US

Inventors

• Phung Tu Gip · San Francisco, US
• Bing Li · Towaco, US
• Matthew P. Greving · San Diego, US
• Matt Lundberg · San Mateo, US
• Mohan Srinivasan · Cupertino, US

Key dates

• Filing date: May 13, 2021
• Grant date: Feb 4, 2025
• Expiry date: Sep 24, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are antibodies that specifically bind to CD25. Also provided herein are methods of making the antibodies described, and methods of use thereof. For example, the CD25 antibodies may be used therapeutically to treat cancer or autoimmune diseases, and in certain aspects: disrupt the trimerization of the beta, gamma, and alpha (CD25) chains of the IL-2 receptor, bind to a different epitope than to which Daclizumab or Baciliximab bind, exhibit a higher affinity of binding to CD25 at a pH lower than 7.4, when compared to the affinity of binding to CD25 at a pH of 7.4, and/or exhibit a higher affinity of binding to CD25 at a pH of about 6.5.