Hybrid immolative cell-penetrating complexes for nucleic acid delivery

US12215341B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Tim R. Blake · Palo Alto, US
• Robert M. Waymouth · Palo Alto, US
• Paul A. Wender · Menlo Park, US
• Ronald Levy · Palo Alto, US
• Ole Haabeth · Emeryville, US
• Matthew FRANK · Palo Alto, US
• Adrienne Sallets · Palo Alto, US

Key dates

• Filing date: Nov 11, 2019
• Grant date: Feb 4, 2025
• Expiry date: May 11, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2239/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.