Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds
US12215359B2 · kind B2 · utility
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Key dates
| Filing date | Apr 23, 2020 |
| Grant date | Feb 4, 2025 |
| Priority date | — |
| Expiry date | Sep 23, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y101/01047
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present application provides engineered glucose dehydrogenase polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.