Modified yeast microorganisms to increase yield of 3-hydropropionic acid
US12215373B1 · kind B1 · utility
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Key dates
| Filing date | Mar 15, 2023 |
| Grant date | Feb 4, 2025 |
| Priority date | — |
| Expiry date | May 6, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions (e.g., engineered hosts) are disclosed for use in converting biomass to 3-hydropropionic acid. In particular embodiments, the methods include use of an engineered Rhodosporidium yeast, such as R. toruloides, the engineered R. toruloides having the RT04_8975 gene deleted from its genome, combined with a lignocellulosic hydrolysate, sourced, for example, from a biomass. A promoter for enhancing transport of 3HP is also incorporated by addition to the R. toruloides genome, for example, by modified lithium acetate transformation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.