Systems and methods for electrophoretic separation and analysis of analytes

US12216080B2 · kind B2 · utility

Assignee

• ProteinSimple · US

Inventors

• Joshua I. Molho · Oakland, US
• Kelly Gardner · Berkeley, US
• Danh C. Tran · Hayward, US
• Eric Jabart · Berkeley, US
• David Nilson · Walnut Creek, US
• Yuri Kouchnir · Sunnyvale, US
• Michael Huston · Vancouver, US
• Colin B. Kennedy · Mill Valley, US
• David J. Roach · Los Gatos, US

Key dates

• Filing date: Dec 23, 2021
• Grant date: Feb 4, 2025
• Expiry date: Apr 12, 2043

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/44756
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.