Amino acid compositions and methods for treating cystic fibrosis
US12220400B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 30, 2019 |
| Grant date | Feb 11, 2025 |
| Priority date | — |
| Expiry date | Apr 6, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are amino acid compositions useful for increasing the translocation of the cystic fibrosis transmembrane conductance (CFTR) protein from the cytoplasm to the plasma membrane, particularly in epithelial cells. Methods for increasing the concentration of CFTR in the plasma membrane, increasing chloride ion transport, and increasing water transport are also provided. These compositions and methods are useful in treating cystic fibrosis in subjects bearing one or more mutations in the CFTR protein. Use of these compositions for the treatment of cystic fibrosis and in the preparation of a medicament for the treatment of cystic fibrosis are also encompassed herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.