Magnetic nano-drug with double targeting VEGF-VEGFR, and preparation method and application thereof

US12220413B2 · kind B2 · utility

Assignee

• The Third Clinical Medical College, Nanjing University of Chinese Medicine · CN

Inventors

• Xin Liu · Wuxi, CN
• Ran Kang · Nanjing, CN
• Lin Xie · Beijing, CN
• Congyang Xue · Nanjing, CN
• Bo Chen · Shantou, CN
• Zihan WANG · Shanghai, CN
• Nan Wang · Chengdu, CN
• Liping Chen · Bethesda, US

Key dates

• Filing date: Jul 8, 2024
• Grant date: Feb 11, 2025
• Expiry date: Jul 8, 2044

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides a magnetic nano-drug with double targeting vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR), and a preparation method and application thereof, and belongs to the technical field of biomedicine. The magnetic nano-drug of the present disclosure includes aminated ZnFe2O4 hollow porous magnetic nano-particles, lactate dehydrogenase-silk fibroin (LDH-SF), ethylene dichloride (EDC), and n-hydroxy succinimide (NHS). A mass ratio of the aminated ZnFe2O4 hollow porous magnetic nano-particles to the EDC to the NHS to the LDH-SF is (5-10):(1-5):(1-6):(1-8).