Method for preparing chiral alkyl compounds by asymmetric hydrogenation of olefins catalyzed by iron complex
US12221409B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 16, 2023 |
| Grant date | Feb 11, 2025 |
| Priority date | — |
| Expiry date | Jul 5, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F15/025
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided in the present invention is a method for preparing chiral alkyl compounds by the asymmetric hydrogenation reaction of iron complex catalysts catalysing olefins: using the disubstituted olefin shown in formula I as a raw material, atmospheric hydrogen as a hydrogen source, FeX2-8-OIQ complex as a catalyst, and a silane compound and acetonitrile as cocatalysts, and reacting for 12-24 hours under the action of a reducing agent to prepare the chiral alkyl compound shown in formula II. The method of the present invention has mild reaction conditions, simple operation, and high atom economy. In addition, the reaction does not require the addition of any other toxic transition metal (such as ruthenium, rhodium, and palladium), and has great practical application value in the synthesis of drugs and materials. The conversion rate of the reaction is also good, generally reaching >99%, and the enantioselectivity is also high, generally 70-99%.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.