Saponin adjuvant and evaluation method thereof
US12221461B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Mar 27, 2019 |
| Grant date | Feb 11, 2025 |
| Priority date | — |
| Expiry date | Jun 15, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8886
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure is related to the six isomer structures (OBI-821-1990-V1A, OBI-821-1990-V1B, OBI-821-1990-V2A, OBI-821-1990-V2B, OBI-821-1858-A, and OBI-821-1858-B) of isolated OBI-821 adjuvant and the method for evaluating the quality thereof. The method of the present disclosure adopts hydrophilic interaction liquid chromatography (HILIC) and reverse phase high performance liquid chromatography (RP-HPLC) either alone or in tandem and is able to separate the isomers of OBI-821 adjuvant in the consequent chromatography. Accordingly, the quality of OBI-821 adjuvant can be further evaluated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.