Method for producing and purifying RNA, comprising at least one step of tangential flow filtration

US12221605B2 · kind B2 · utility

Assignee

• CureVac Manufacturing GmbH · DE

Inventors

• Andreas FUNKNER · Tübingen, DE
• Stefanie DORNER · Tübingen, DE
• Stefanie SEWING · Tübingen, DE
• Johannes KAMM · Tübingen, DE
• Norbert BROGHAMMER · Tübingen, DE
• Thomas Ketterer · Bingen, DE
• Thorsten MUTZKE · Reutlingen, DE

Key dates

• Filing date: Oct 23, 2023
• Grant date: Feb 11, 2025
• Expiry date: Oct 23, 2043

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/027
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).