Method for producing recombinant hyaluronidase
US12221638B2 · kind B2 · utility
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19References
15Claims
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Key dates
| Filing date | Aug 6, 2021 |
| Grant date | Feb 11, 2025 |
| Priority date | — |
| Expiry date | Aug 6, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y302/01035
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.