Patent · US Active

1-isopropyl-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (ATM) kinase and uses thereof

US12226414B2 · kind B2 · utility

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16Claims

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Assignee

SUZHOU ZANRONG PHARMA LIMITED · CN

Inventors

Ding Zhou · Shanghai, CN
Ziqiang CHENG · Shanghai, CN

Key dates

Filing date	Sep 16, 2019
Grant date	Feb 18, 2025
Priority date	—
Expiry date	Jun 29, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application relates to novel substituted imidazo[4,5-c]cinnolin-2-one compounds and pharmaceutically acceptable salts thereof, which selectively modulate ataxia telangiectasia mutated (“ATM”) kinase. The present application also relates to pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and to the use of the compounds and salts thereof in the treatment of ATM-associated diseases or conditions, including cancers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.