Patent · US Active

Small molecule degraders of Helios and methods of use

US12227488B2 · kind B2 · utility

0Cited by

1References

47Claims

0Family size

Assignee

DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

Alyssa Verano · New York, US
Eric Wang · Brookline, US
Radoslaw Nowak · Boston, US
Jing Yuan · Lansdale, US
Nathanael S. Gray · Boston, US
Eric Fischer · East Sharon, US
Tinghu Zhang · Brookline, US
Hu Liu · Beijing, CN

Key dates

Filing date	Dec 3, 2019
Grant date	Feb 18, 2025
Priority date	—
Expiry date	Mar 29, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders characterized or mediated by aberrant protein activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.