Preparation of maytansinol
US12227519B2 · kind B2 · utility
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4References
11Claims
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Key dates
| Filing date | Feb 28, 2020 |
| Grant date | Feb 18, 2025 |
| Priority date | — |
| Expiry date | Oct 29, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A scaled process of preparing maytansinol, FORMULA II, is provided by reacting a compound of Formula I, wherein R is selected from the group consisting essentially of alkyl, branched alkyl, aryl, alkenyl, alkynyl, as well as substituted variations thereof, with at least one organometallic reagent to produce the compound of Formula II; and, isolating the compound of Formula II.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.