Patent · US Active

De novo design of potent and selective interleukin mimetics

US12227553B2 · kind B2 · utility

0Cited by

10References

13Claims

0Family size

Assignees

University of Washington · US
The Board of Trustees of the Leland Stanford Junior University · US

Inventors

Daniel Adriano Silva Manzano · Seattle, US
Shawn Yu · Seattle, US
Umut Ulge · Seattle, US
David Baker · Ann Arbor, US
Kenan Christopher Garcia · Menlo Park, US
Jamie Spangler · Seattle, US
Carl Walkey · Seattle, US

Key dates

Filing date	Mar 21, 2023
Grant date	Feb 18, 2025
Priority date	—
Expiry date	Mar 21, 2043

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.