Anti-CD3 constructs and uses thereof
US12227574B2 · kind B2 · utility
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29References
19Claims
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Key dates
| Filing date | Jun 16, 2022 |
| Grant date | Feb 18, 2025 |
| Priority date | — |
| Expiry date | Jun 16, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/732
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides tumor microenvironment acidity activated anti-CD3 constructs that bind to CD3 (e.g., anti-CD3 monoclonal and multispecific antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-CD3, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-CD3 construct, pharmaceutical compositions containing the anti-CD3 construct, and methods of using the anti-CD3 construct or compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.