Expansion microscopy compatible anchorable HandE staining for histopathology
US12228481B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Dec 31, 2019 |
| Grant date | Feb 18, 2025 |
| Priority date | — |
| Expiry date | Jul 24, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG02B21/36
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A technique for expansion microscopy (ExM) utilizing anchorable derivatives of hematoxylin and eosin (H&E) stained tissue specimens within tissue samples, in order to achieve high resolution detection of biomolecules with precise morphological features of cells and nuclei, which in turn, allows for effective for accurate early stage disease diagnosis including various cancers. Staining with H&E employs anchorable derivatives that can be cross-linked into the ExM hydrogel matrix.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.