Oral solid tablet comprising Bruton's Tyrosine Kinase inhibitor and preparation method therefor

US12233069B2 · kind B2 · utility

Assignee

• Beigene Switzerland GMBH · CH

Inventors

• Gang Qiu · Beijing, CN
• Yiwei Shen · Beijing, CN
• Wenyuan FAN · Beijing, CN
• Shuo Xu · Nanchang, CN
• Huiru LV · Beijing, CN
• Jialin Bian · Beijing, CN
• Zhengming Du · Beijing, CN

Key dates

• Filing date: Nov 13, 2023
• Grant date: Feb 25, 2025
• Expiry date: Nov 13, 2043

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2866
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are an oral solid tablet comprising (S)-7-[4-(1-acryloylpiperidine)]-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and preparation method therefor. The oral solid tablet has good drug release characteristics, features easy administration, quick and high-efficient release, no particular requirements on equipment, and a simple formulation preparation process, can ensure formulation stability and facilitate transportation and storage, and is suitable for large-scale production.