Compositions and methods for promoting islet viability and enhancing insulin secretion
US12233108B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 13, 2020 |
| Grant date | Feb 25, 2025 |
| Priority date | — |
| Expiry date | Jul 22, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P5/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for regenerating pancreatic islet viability and/or cell proliferation in vitro, ex vivo, and/or in vivo; and/or for regenerating glucose-stimulated insulin secretion; and/or for regenerating viability and/or cell proliferation of a transplanted pancreatic islets; and/or for preventing and/or inhibiting rejection of a transplanted islets; and/or for pancreatic islet transplantation; and/or for treating a symptom of a condition, disorder, or disease associated with abnormal insulin responsiveness to glucose are provided. In some embodiments, the compositions include a peptide and/or a pharmaceutically acceptable salt thereof, and/or a biologically active fragment, analog, or derivative thereof, wherein the peptide, the pharmaceutically acceptable salt thereof, and/or the biologically active fragment, analog, or derivative thereof has an amino acid sequence of any of SEQ ID NOs: 1-60, or any combination thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.