Nonfouling compositions and methods for manipulating and processing encapsulated droplets
US12233390B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 31, 2020 |
| Grant date | Feb 25, 2025 |
| Priority date | — |
| Expiry date | Apr 13, 2042 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L7/525
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Compositions for preventing or limiting surface fouling as well as evaporation and methods for their use in air-matrix digital microfluidics (DMF) apparatuses are described. A mobilizing wax material may be used to selectively encapsulate a reaction droplet in the air gap of the apparatus, which permits the at least partially encapsulated reaction droplet to be portable within the DMF apparatus. Additional aqueous droplets may be combined with the encapsulated droplet, by merging with an aqueous droplet having a coating of a secondary material (e.g., an oil or other hydrophobic material) that may allow combining of the droplets. The compositions may be additionally useful in non-DMF applications such as laboratory protocols for hybridization, ligation and amplification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.