Synthetic methods of preparing esketamine
US12234200B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Apr 16, 2020 |
| Grant date | Feb 25, 2025 |
| Priority date | — |
| Expiry date | Nov 23, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2′-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1′-biphenyl]-3-yl carbamate to (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.