3,4-dihydroxy-n-(1′-benzyl-2′-hydroxyethyl)-2-methylpyridine chloride, and synthesis and use thereof
US12234208B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 2022 |
| Grant date | Feb 25, 2025 |
| Priority date | — |
| Expiry date | Nov 16, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/69
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present application provides the preparation and use of a 3,4-dihydroxyl-N-(1′-benzyl-2′-hydroxyethyl)-2-methyl pyridine chloride. According to the present application, a 3,4-dihydroxyl-N-(1′-benzyl-2′-hydroxyethyl)-2-methyl pyridine chloride is directly synthesized by a one-step reaction, and the compound includes a pharmaceutically acceptable salt thereof. 3,4-dihydroxyl-N-(1′-benzyl-2′-hydroxyethyl)-2-methyl pyridine chloride has been proved to have a good antiparkinsonian activity by animal tests, and it is a class of novel antiparkinsonian drug candidates. It can be used in the preparation of drugs for the treatment of a Parkinson's disease, and its structural formula (I) is as follows:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.