Piperazine amide derivative, preparation method therefor, and use thereof in medicine
US12234222B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Apr 9, 2020 |
| Grant date | Feb 25, 2025 |
| Priority date | — |
| Expiry date | May 2, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a piperazine amide derivative as represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, and use of same as a therapeutic agent, especially as a selective Rearranged During Transfection (RET) kinase inhibitor. Ring a, ring e, X1, X2, X3, X4, R1, R2, R3, R4, R4′, R5, R5′, R6, R6′, R7, R7′, R8, m and n have the same definitions as those in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.