Aromatic heterocyclic compound with kinase inhibitory activity

US12234232B2 · kind B2 · utility

Assignee

• SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD. · CN

Inventors

• Lei Jiang · Shanghai, CN
• Jianwen DENG · Shanghai, CN
• Zhiyong FENG · Shanghai, CN
• Shengyang LIU · Shanghai, CN
• Xudong MAO · Shanghai, CN
• Ke Shang · Beijing, CN
• Jianyong SHOU · Fremont, US
• Danyi Wu · Shanghai, CN
• Xiaoping XIE · Shanghai, CN
• Yuan Xu · Singapore, SG
• Haixia ZHAO · Shanghai, CN
• Jianhua Zhang · Tangxia, CN
• Mingwei Zheng · Shanghai, CN

Key dates

• Filing date: Sep 23, 2019
• Grant date: Feb 25, 2025
• Expiry date: May 14, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are a JAK kinase inhibitor, preparation and use thereof. In particular, provided is a compound of Formula I, wherein each group is as described in the specification. The compound has an excellent JAK inhibitory activity, and therefore can be used to prepare pharmaceutical compositions for the treatment of cancer and other diseases related to JAK activity.