Patent · US Active

Method for synthesizing 1,7-naphthyridine derivatives

US12234234B2 · kind B2 · utility

0Cited by

1References

13Claims

0Family size

Assignee

CHENGDA PHARMACEUTICALS CO., LTD. · CN

Inventors

Wei Qian · Dalian, CN
Yuhua Shi · Shanghai, CN
Xing Huang · Chongqing, CN
Changming Dong · Guizhou, CN
Junkui Dang · Huangyang, CN
Zhipeng Wang · Hainan, CN
Yu Feng · Cliffside Park, US
Hong-Zong Xu · Zhejiang, CN
Zongxi Huang · Daguantang, CN
Ye Chen · Hangzhou City, CN
Huafei Shen · Zhejiang, CN
Jun Zhang · Xiamen, CN

Key dates

Filing date	Nov 17, 2020
Grant date	Feb 25, 2025
Priority date	—
Expiry date	Nov 11, 2042

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention discloses a method for synthesizing 1,7-naphthyridine derivatives, which relates to the technical field of synthesizing pharmaceutical intermediates and organic chemical intermediates, wherein the method includes: (1) 2-chloro-3-amino-pyridine being used as Compound I as a starting material, and protecting an amino group to prepare Compound II; (2) the Compound II reacting with an aldehydation reagent under alkaline conditions to obtain Compound III; (3) cyclizing the Compound III with acrylate compounds under the action of Lewis acid to prepare compound IV.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.