Anti-PHF-tau antibodies and uses thereof

US12234280B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Kristof Van Kolen · Haacht, BE
• Marc Mercken · Turnhout, BE
• Linda Barone · Exton, US
• Eilyn Lacy · Spring House, US
• Rupesh Nanjunda · Hatfield, US
• John Wheeler · Spring House, US
• Jinquan Luo · Malvern, US
• Marianne Borgers · Balen, BE

Key dates

• Filing date: Mar 4, 2019
• Grant date: Feb 25, 2025
• Expiry date: Jun 22, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2835
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Monoclonal anti-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies. The antibodies of the invention may also be used to quantify tau in biological samples.