Targeted non-viral DNA insertions

US12234461B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION · US

Inventors

• Theodore Lee Roth · San Francisco, US
• Alexander Marson · San Francisco, US

Key dates

• Filing date: Sep 8, 2023
• Grant date: Feb 25, 2025
• Expiry date: Sep 8, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell.