Humanized anti-BASIGIN antibodies and the use thereof

US12240901B2 · kind B2 · utility

Assignee

• FOURTH MILITARY MEDICAL UNIVERSITY · CN

Inventors

• Zhinan Chen · Dizhai, CN
• Ping Zhu · Boxborough, US
• Wan HUANG
• Zheng Zhang · Beijing, CN
• Yang Zhang · San Diego, US
• Mengyao ZHANG · Tuji, CN
• Huijie BIAN · Tuji, CN
• Jianli JIANG · Tuji, CN

Key dates

• Filing date: May 2, 2017
• Grant date: Mar 4, 2025
• Expiry date: Apr 26, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides a humanized anti-BASIGIN antibody or antigen binding fragment thereof, which comprises heavy chain variable region (VH) comprising an amino acid sequence of SEQ ID NO: 1; optionally further comprise light chain variable region (VL) comprising an amino acid sequence of SEQ ID NO: 2. The present disclosure also provides a composition comprising the humanized anti-BASIGIN antibody or antigen binding fragment thereof, an isolated nucleic acid sequence encoding the humanized anti-BASIGIN antibody or antigen binding fragment thereof, a vector comprising the nucleic acid, a host cell comprising the vector, and use of the humanized anti-BASIGIN antibody or antigen binding fragment thereof.