N-terminal scFv multispecific binding molecules

US12240908B2 · kind B2 · utility

Assignee

• REGENERON PHARMACEUTICALS, INC. · US

Inventors

• Yang Shen · Shanghai, CN
• Ann-Hwee Lee · Ardsley, US
• Yan Yang · Mamaroneck, US
• Chia-Yang Lin · Palo Alto, US

Key dates

• Filing date: Apr 22, 2022
• Grant date: Mar 4, 2025
• Expiry date: Apr 22, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Multispecific binding molecules (MBMs) comprising an N-terminal scFv, a first Fab and a second Fab, MBM conjugates comprising the MBMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the MBMs and MBM conjugates, methods of using the MBMs, MBM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the MBMs, cells engineered to express the MBMs, and methods of producing MBMs.