Multi-compartment device containing human three-dimensional (3D) microtissues for toxicity testing
US12241049B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 9, 2020 |
| Grant date | Mar 4, 2025 |
| Priority date | — |
| Expiry date | Feb 28, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5088
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This dual-compartment liver co-culture system exposes target microtissue to metabolites, allowing for evaluating toxicity using a standard multi-well plate for high throughput analysis. Discovery scientists can rapidly select lead compounds with desirable metabolic profiles, while safety scientists can determine the safety of drugs, pesticides, and environmental chemicals. This platform is allometrically scalable, so it can mimic the natural size differences between healthy organs and, with the liver, produce sufficient quantities of metabolites. The device is simple to use and designed for immediate in vitro pathology assessment using confocal microscopy, transcriptomics, and proteomics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.