Molecular assessment of TRBC usage
US12241124B2 · kind B2 · utility
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Key dates
| Filing date | Jul 18, 2019 |
| Grant date | Mar 4, 2025 |
| Priority date | — |
| Expiry date | Jun 9, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a method of determining the T cell receptor β chain (TRBC) gene type of a cell, the method comprising (a) determining the J gene type expressed in said cell, and (b) inferring from (a) the TRBC gene type expressed in said cell. The invention further relates to use of a CAR T cell targeted to a T cell receptor β chain (TRBC) type 1, or a CAR T cell targeted to a T cell receptor β chain (TRBC) type 2. The invention further relates to a method of medical treatment, and to nucleic acid probes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.