Omega-alicyclic tunicamycins and analogs
US12245589B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Apr 12, 2022 |
| Grant date | Mar 11, 2025 |
| Priority date | — |
| Expiry date | Jul 29, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to new tunicamycin structures comprising N-acyl groups metabolically integrated into the terminus of the TUN via the Streptomyces branched chain fatty acid pathways and variants thereof, and methods of preparing such new tunicamycin structures. The invention further relates to antibacterial compositions comprising such new tunicamycin structures, and methods for using such antibacterial compositions for killing Gram-positive bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.