Crosslinkers for mass spectrometric identification and quantitation of interacting peptides
US12247009B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Mar 10, 2017 |
| Grant date | Mar 11, 2025 |
| Priority date | — |
| Expiry date | Sep 3, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2560/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Crosslinking molecules that permit efficient identification of specifically associated proteins and the sites of crosslinking in biological or other samples include two cleavable bonds that are cleavable under the same conditions as peptide bonds in mass spectrometric determinations. Sets of the invention crosslinkers may be provided with isobaric labels containing reporter ions of differing molecular weights to permit relative quantitation of crosslinked protein pairs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.