IL-21 polypeptides and targeted constructs
US12247072B2 · kind B2 · utility
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30Claims
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Assignee
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Key dates
| Filing date | Apr 27, 2023 |
| Grant date | Mar 11, 2025 |
| Priority date | — |
| Expiry date | Apr 27, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.