Patent · US Active

Glycosylated lysosomal proteins, method of production and uses

US12247215B2 · kind B2 · utility

0Cited by

3References

11Claims

0Family size

Assignee

ELEVA GMBH · DE

Inventors

Paulina Dabrowska-Schlepp · Denzlingen, DE
Fode Benjamin · Denzlingen, DE
Andreas Busch · Tirol, DE
Holger Niederkrüger · Malterdingen, DE
Andreas Schaaf · Mittenaar, DE

Key dates

Filing date	Apr 25, 2022
Grant date	Mar 11, 2025
Priority date	—
Expiry date	Apr 25, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y302/01045
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be α-Galactosidase for the treatment of Fabry Disease or β-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.