Cellular reprogramming using temporal and transient plasmid vector expression system
US12247226B2 · kind B2 · utility
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Key dates
| Filing date | Oct 10, 2018 |
| Grant date | Mar 11, 2025 |
| Priority date | — |
| Expiry date | Feb 14, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are methods and compositions for inducing the reprogramming of a non-pluripotent to an iPSC having desirable properties using a vector system providing transient and temporal expression of transgenes that are short-lived. Also provided are reprogramming cells and iPSC populations or clonal cell lines using the provided reprogramming methods and compositions. Further provided are genome-engineered iPSCs and derived cells redifferentiated therefrom to comprise targeted editing involving insertions and deletions in one or more selected genomic loci.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.