Patent · US Active

Method of improved sequencing by strand identification

US12247252B2 · kind B2 · utility

0Cited by

122References

8Claims

0Family size

Assignee

ACCURAGEN HOLDINGS LIMITED · KY

Inventors

Malek Faham · Pacifica, US
Shengrong Lin · Hayward, US
Ling Fung TANG · San Francisco, US
Yontao LU · Sunnyvale, US
Zhaohui Sun · Rochester, US
Yingyu Wang · Mountain View, US
Li Weng · Fremont, US

Key dates

Filing date	Jul 28, 2022
Grant date	Mar 11, 2025
Priority date	—
Expiry date	Apr 17, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2537/143
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

In some aspects, the present disclosure provides methods for identifying sequence variants, as well as methods of determining copy number of a genetic locus in a sample. Systems and kits for performing methods of the disclosure, as well as compositions produced by or useful in methods of the disclosure are also provided. In some embodiments, methods comprise extending 3′ ends of polynucleotides by adding one or more pre-determined nucleotides. In some embodiments, methods comprise use of a strand-tagging sequence.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.