Method for measuring intracellular potential with a capacitance type potential measurement device
US12247972B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 26, 2019 |
| Grant date | Mar 11, 2025 |
| Priority date | — |
| Expiry date | May 25, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54346
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The purpose of the present invention is to provide a method for accurately measuring and controlling intracellular potential by a simple method that is less invasive to the cell and does not require a skilled technique. The method according to the present invention comprises: by using magnetic force from a magnetic electrode adhered to the surface of a target cell, into which conductive nanoparticles have been preliminarily introduced, or a magnet being in contact with a conductive plate electrode, attracting the conductive nanoparticles inside the cell to the side of the cell surface adhering to the electrode, and then allowing the conductive nanoparticles to pass through the cell membrane to thereby bring the end outside the cell into contact with the magnetic electrode or the conductive plate electrode; or alternatively, adhering the conductive nanoparticles adsorbed on the magnetic electrode surface to the upper side of the target cell, and allowing the conductive nanoparticles to pass through the cell membrane by attracting the conductive nanoparticles to an iron plate disposed on the lower side of the cell to thereby leave the end outside the cell being in contact with the ma…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.