Genetically modified mouse with a humanized PNPLA3 gene and methods of use
US12250931B2 · kind B2 · utility
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Key dates
| Filing date | Jan 27, 2021 |
| Grant date | Mar 18, 2025 |
| Priority date | — |
| Expiry date | Oct 25, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized PNPLA3 locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized PNPLA3 locus express a human PNPLA3 protein or a chimeric PNPLA3 protein, fragments of which are from human PNPLA3. Methods are provided for using such non-human animals comprising a humanized PNPLA3 locus to assess in vivo efficacy of human-PNPLA3-targeting reagents such as nuclease agents designed to target human PNPLA3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.