Use of effective part extract of Monochasma savatieri in preparation of drug for treating inflammatory disease or tumor

US12251413B2 · kind B2 · utility

Assignees

• HARBIN KANGLONG PHARMACEUTICAL CO., LTD · CN
• YICHUN BINGCHEN AGRICULTURAL TECHNOLOGY DEVELOPMENT CO., LTD · CN

Inventors

• Bin Mu · Tempe, US
• Jiangong Shi · Beijing, CN
• Tiantai Zhang · Jingwei, CN
• Qinglan Guo · Jingwei, CN
• Weiquan Li · Jiangmen, CN

Key dates

• Filing date: Sep 5, 2022
• Grant date: Mar 18, 2025
• Expiry date: Sep 5, 2042

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides use of an effective part extract of Monochasma savatieri in preparation of a drug for treating an inflammatory disease or a tumor. In the present disclosure, an effective part of Monochasma savatieri is separated and purified by various separation and purification methods (including solvent extraction, macroporous resin column chromatography, MCI column separation, and Sephadex LH-20 gel column separation) separately, to obtain the effective part extract of Monochasma savatieri. The effective part extract of Monochasma savatieri is capable of significantly inhibiting secretion of TNF-α, and significantly inhibiting proliferation of breast cancer cells and lung cancer cells, thereby effectively treating the inflammatory disease or the tumor. The present disclosure provides a favorable theoretical basis for finding a drug that can effectively treat the inflammatory disease or the tumor from the Monochasma savatieri, which is of great significance to development of novel drugs.