Methods and compositions for RNA-guided treatment of HIV infection

US12251429B2 · kind B2 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• Kamel Khalili · Yeadon, US
• Wenhui Hu · 流花街道, CN
• Yonggang Zhang · Suzhou, CN

Key dates

• Filing date: Sep 10, 2020
• Grant date: Mar 18, 2025
• Expiry date: Sep 10, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/11
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to one or more target nucleic acid sequences in a retrovirus genome.